Human ANGPTL7 / CDT6 Protein, Mouse IgG2a Fc Tag

Source : 

Human ANGPTL7, Mouse IgG2a Fc Tag (AN7-H5252) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Pro 346 (Accession # O43827-1).

 

Molecule : ANGPTL7

 

Synonyms : ANGPTL7,CDT6

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_066969.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 64.1 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 64.1 kDa. The protein migrates as 60 kDa and 76 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Angiopoietin-like 7 (ANGPTL7) is also known as Corneal-Derived Transcript 6 (CDT6), and is a secreted glycoprotein that is structurally related to the angiopoietins. It is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells.

 

References :

(1) Peek R., et al., 1998, Invest. Opthalmol. Visual Sci. 39 (10): 1782-1788.
(2) Peek R., et al., 2002, J. Biol. Chem. 277 (1): 686-693.
(3) Kuchtey, J. et al., 2008, Invest. Opthalmol. Visual Sci. 49 (8): 3438-3448.