Human ANGPTL7 / CDT6 Protein, His Tag

Source : 

Human ANGPTL7, His Tag (AN7-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 27 - Pro 346 (Accession # O43827-1).

 

Molecule : ANGPTL7

 

Synonyms : ANGPTL7,CDT6

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_066969.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 39.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 38-40 kDa and 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Angiopoietin-like 7 (ANGPTL7) is also known as Corneal-Derived Transcript 6 (CDT6), and is a secreted glycoprotein that is structurally related to the angiopoietins. It is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells.

 

References :

(1) Peek R., et al., 1998, Invest. Opthalmol. Visual Sci. 39 (10): 1782-1788.
(2) Peek R., et al., 2002, J. Biol. Chem. 277 (1): 686-693.
(3) Kuchtey, J. et al., 2008, Invest. Opthalmol. Visual Sci. 49 (8): 3438-3448.