Human Angiopoietin-like 4 / ANGPTL4 (166-406) Protein, His Tag

Source : 

Human Angiopoietin-like 4 (166-406), His Tag (AN4-H5243) is expressed from human 293 cells (HEK293). It contains AA Pro 166 - Ser 406 (Accession # Q9BY76-1).

 

Molecule : Angiopoietin-like 4

 

Synonyms : ANGPTL4,ANGPTL2,ARP4,FIAF,HFARP,NL2,PGAR,pp1158,Angiopoietin like 4

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_647475.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 27.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM MOPS, 100 mM NaCl, pH7.2

 

Description :

Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR. ANGPTL4 contains one fibrinogen C-terminal domain. ANGPTL4 is a homooligomer , and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action.

 

References :

(1) Yoon J.C., et al., 2000, Mol. Cell. Biol. 20:5343-5349.
(2) Ito Y., et al., 2003, Cancer Res. 63:6651-6657.
(3) Zhu H., et al., 2002, Zhonghua Zhong Liu Za Zhi 24:123-125.