Human ALK-1 / ACVRL1 Protein (Fc Tag)

Species : Human

Synonyms : ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,SKR3,TSR-I

Host : HEK293 Cells

Purity :> 97 % as determined by SDS-PAGE

Activity : 1. Measured by its ability to bind Human ENG-Fc (Cat:10149-H02H) in functional Elisa.
2. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.