Human AIMP1 / EMAP2 / SCYE1 Protein, His Tag

Source : 

Human AIMP1, His Tag (EM2-H5142) is expressed from E.coli cells. It contains AA Ala 2 - Lys 312 (Accession # Q12904-1).

 

Molecule : AIMP1

 

Synonyms : AIMP1,EMAP2,EMAPII,HLD3,SCYE1,p43,EMAP-2,EMAP-II,AIMP-1

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : AAH14051.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 35.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.2 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II). AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.

 

References :

(1) Barnett G., et al., 2000, Cancer Res. 60:2850-2857.
(2) Park S.G., et al., 1999, J. Biol. Chem. 274:16673-16676.
(3) Tandle A.T., et al., 2009, Exp. Cell Res. 315:1850-1859.