Human Adiponectin / ADIPOQ Protein, Fc Tag

Source : 

Human ADIPOQ, Fc Tag (ADQ-H5250) is expressed from human 293 cells (HEK293). It contains AA Glu 19 - Asn 244 (Accession # NP_001171271).

 

Molecule : Adiponectin

 

Synonyms : ADIPOQ,Adiponectin,ACDC,ACRP30,APM1,GBP28

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_001171271

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 51.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.2 kDa. The protein migrates as 54-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Adiponectin is also referred to as GBP-28, APM1, ADIPOQ, ACDC and Acrp30, is a secreted protein which contains one C1q domain (commonly called the globular domain) and onecollagen-like domain. Adiponectin / ADIPOQ is synthesized exclusively by adipocytes and secreted into plasma. ADIPOQ is important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Acrp30 Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway and may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

 

References :

(1) Nakano Y., et al., 1996, J. Biochem. 120:803-812.
(2) Yamauchi T., et al., 2001, Nat. Med. 7:941-946.
(3) Richards A.A., et al., 2006, Mol. Endocrinol. 20:1673-1687.