Human ADAM8 / CD156a Protein, His Tag

Source : 

Human ADAM8, His Tag (AD8-H5223) is expressed from human 293 cells (HEK293). It contains AA Ile 17 - Pro 497 (Accession # AAI15405.1).

 

Molecule : ADAM8

 

Synonyms : ADAM8,MS2,CD156a

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAI15405.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 53.8 kDa

 

Characteristics :

Human ADAM8, His Tag fused with a polyhistidine tag at the C-terminus, has a calculated MW of 53.8 kDa, which migrates as a 180-220 kDa band in DTT-reduced SDS-PAGE due to glycosylation. Two main fragments bands are visible with apparent MW of 69-73 kDa a

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Disintegrin and metalloproteinase domain-containing protein 8 is also known as ADAM8, Cell surface antigen MS2 and CD antigen CD156a, which belongs to the ADAM (a disintegrin and metalloprotease domain) family. ADAM family play a fundamental role in diverse processes such as asthma, development, angiogenesis and cancer through their activities in cell adhesion/fusion, membrane protein shedding, and signal transduction. ADAM8 / CD156a contains 1 disintegrin domain, 1 EGF-like domain and 1 peptidase M12B domain. ADAM8 / MS2 / CD156a is expressed on neutrophils and monocytes. ADAM8 / MS2 possible involvement in extravasation of leukocytes.

 

References :

(1) Yoshiyama K., et al., 1997, Genomics 41 (1): 56–62.
(2) Hall T., et al., 2012, Acta Crystallogr. F 68:616-621.