Human Activin RIB / ACVR1B Protein, His Tag

Source : 

Human Activin RIB, His Tag (ACB-H52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Glu 126 (Accession # P36896-1).

 

Molecule : Activin RIB

 

Synonyms : ACVR1b,ALK4,ACVRLK4,ACTR-IB,SKR2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH00254

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 13.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.3 kDa. The protein migrates as 16-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is “ATP + [receptor-protein] = ADP + [receptor-protein] phosphate”. ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1.

 

References :

(1) Carcamo J., et al., 1994, Mol. Cell. Biol. 14:3810-3821.
(2) Suzuki K., et al., 2010, Biochem. Biophys. Res. Commun. 394:639-645.
(3) Harrison C.A., et al., 2003, J. Biol. Chem. 278:21129-21135.