Human 4-1BB Ligand / TNFSF9 Protein, Mouse IgG2a Fc Tag, low endotoxin

Source : 

Human 4-1BB Ligand, Mouse IgG2a Fc Tag, low endotoxin (41L-H5254) is expressed from human 293 cells (HEK293). It contains AA Ala 50 - Glu 254 (Accession # P41273-1).

 

Molecule : 4-1BB Ligand

 

Synonyms : 4-1BB Ligand,TNFSF9,CD137L

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_003802.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.3 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 48.3 kDa. The protein migrates as 47-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

 

References :

(1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.
(2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.