Human 4-1BB Ligand / TNFSF9 (71-254) Protein, His,Flag Tag (active trimer) (MALS verified)

Source : 

Human 4-1BB Ligand (71-254), His,Flag Tag (active trimer) (MALS verified) (41L-H52D4) is expressed from human 293 cells (HEK293). It contains AA Arg 71 - Glu 254 (Accession # P41273-1) trimer Design.

 

Molecule : 4-1BB Ligand

 

Synonyms : 4-1BB Ligand,TNFSF9,CD137L

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_003802.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The protein has a calculated MW of 62.8 kDa. The protein migrates as 55-60 kDa under non-reducing (NR) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

 

References :

(1) Won E.Y., et al., 2010, J. Biol. Chem. 285:9202-9210.
(2) Alderson M.R., et al., 1994, Eur. J. Immunol. 24:2219-2227.