Human 2B4 / CD244 / SLAMF4 Protein, His Tag

Source : 

Human 2B4, His Tag (2B4-H5224) is expressed from human 293 cells (HEK293). It contains AA Cys 22 - Arg 221 (Accession # NP_057466).

 

Molecule : 2B4

 

Synonyms : CD244,2B4,SLAMF4,NKR2B4,NAIL,h2B4

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_057466

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 23.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.1 kDa. The protein migrates as 35-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

 

References :

(1) Nakajima H., et al., 1999, Eur. J. Immunol. 29:1676-1683.
(2) Kubin M.Z., et al., 1999, Eur. J. Immunol. 29:3466-3477.
(3) Boles K.S., et al., 1999, Tissue Antigens 54:27-34.