hPersephin

hPersephin

 

Product#:

P-320

Sizes:

1 μg

5 x 1 μg

5 μg

EconoSize! 10 μg

Persephin is a novel neurotrophic factor related to GDNF and Neurturin in the  

GDNF subfamily.¹ Persephin is ubiquitously expressed, although at very low levels.² 

In sharp contrast to GDNF and Neurturin, Persephin does not support the survival of neurons 

from peripheral ganglia including sympathetic and parasympathetic neurons, sensory neurons  

and enteric neurons.^1,3 Persephin does promote the survival of midbrain dopaminergic neurons 

after neurotoxic injury and the survival of spinal motor neurons in vitro and in vivo animal models. 



The receptor for Persephin is a multi-component complex composed of RET tyrosine kinase and the  

glycosyl-phosphatidylinositol (GPI)-anchored co-receptor GFRalpha1-alpha4.^4,5 



Persephin induces, in vitro, branching of the ureteric bud of the kidney, an activity shared by  

Neurturin and GDNF.¹ Both in vitro and in vivo experiments using animal models suggest  

that Persephin could be useful in the treatment of neurodegenerative diseases including  

Parkinson's disease and Amyotrophic Lateral Sclerosis (ALS).⁶

Preparation:

hPersephin is a recombinant growth factor produced in E. coli.

M.W.:

20.6 kDa.

Purity:

Greater than 98% as estimated by SDS-PAGE analysis.

Bioassay:

The activity was determined by the induction of RET phosphorylation using   a concentration range of 0.1-1 ng/ml. hPersephin binds to mammalian GFRα4 with KD of 100pM.

Locus Link ID:

5623 Persephin .

References:

1.	Milbrandt, J. et al. (1998) Neuron 20, 245.
2.	Jaszai, J. et al. (1998) J. Neurosci. Res. 53, 494.
3.	Bilak, M.M. et al. (1999) Mol. Cell. Neurosci. 13, 326.
4.	Enokido, Y.et al. (1998) Curr. Biol. 8, 12999.
5.	Masure, S.et al. (2000) J. Biol. Chem. 275, 39427.
6.	Akerud, P. et al. (2002) Mol. Cell. Neurosci. 21, 205.