Homocysteine HPLC

Homocysteine exists in plasma as protein-bound and, so-called, free forms. About
70 percent of the total plasma homocysteine is bound to albumin. The free forms
include homocystine (homocysteine disulphide) and mixed disulphide. Just minute
amounts of reduced homocysteine are found in plasma. Total homocysteine in plasma,
including protein-bound and free forms, has been referred as homocyst(e)ine
[H(e)]. Studies for peripheral vascular, cerebrovascular and coronary artery disease
(CAD), evaluating H(e) as a cardiovascular risk factor, have been consistently demonstrated
that there are more persons with high H(e) among patients than among
healthy persons. Increased concentrations of free forms of homocysteine have also
generally been reported among patients with occlusive artery disease, with one notable
exception of a negative finding in relation to CAD.