His6-USP2CD
- 貨號 Cat. No.
- E-506
- 規格 Size
- 50 μg
- 品牌 Brand
- Boston Biochem
Description
His6-USP2CD
human recombinant
Product Information
50 μg
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 150 mM NaCl, 10% glycerol, 0.5 mM EDTA, 1mM DTT. Actual concentration varies with specific Lot #
42 kDa
> 95% by SDS-PAGE
Catalog #: E-506
His6-USP2CD
Product Source:
human recombinant
Also known as: His6-USP2CD (UBP41 catalytic domain)
USP2 (Ubiquitin Specific Protease 2) is a cysteine protease over-expressed in prostate cancer, is androgen-regulated and interacts with and prolongs the half-life of fatty acid synthase (FAS). FAS stabilization is associated with the malignancy of a subset of aggressive prostate cancers. Mdm2 is also a substrate for USP2 indicating that the enzyme may regulate p53-dependent pathways. The in vivo and in vitro oncogenic properties of USP2 are also linked to its deubiquitinating activity. It has been hypothesized that USP2 might stabilize short-lived proteins that accumulate and may act as regulators or effectors in the induction of apoptosis. This recombinant protein contains a C-terminal his-tag and residues 259-605 representing the catalytic domain (CD) of USP2. Accession # NP_004196.
Product Information
Quantity:
50 μg
Stock:
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 150 mM NaCl, 10% glycerol, 0.5 mM EDTA, 1mM DTT. Actual concentration varies with specific Lot #
MW:
42 kDa
Purity:
> 95% by SDS-PAGE