Kits
hGH ELISA
Kits
Description
Growth hormone is a polypeptide hormone
synthesised and secreted by the anterior pituitary
gland which stimulates growth and cell reproduction in
humans and other vertebrate animals.
GH is released from the pituitary into the bloodstream
in a pulsatile manner under the regulatory control of
hypothalamic somatostatin (SS) and GH-releasing
factor (GHRF).
Stimulators of GH secretion include, exercise,
hypoglycemia, dietary protein, and estradiol. Inhibitors
of GH secretion include dietary carbhoydrate and
glucocorticoids.
Almost 50% of GH in circulation is bound to a high
affinity GH binding protein (GHBP), which represents
the extracellular domain of the GH receptor.
The plasma concentration of GH during these peaks
may range from 5 to 30 ng/mL or more. Peaks
typically last from 10 to 30 minutes before returning to
basal levels. The largest and most predictable of
these GH peaks occurs about an hour after onset of
sleep. Otherwise there is wide variation between days
and individuals. Between the peaks, basal GH levels
are low, usually less than 3 ng/mL for most of the day
and night.
The amount and pattern of GH secretion change
throughout life. Basal levels are highest in early
childhood. The amplitude and frequency of peaks is
greatest during the pubertal growth. Healthy children
and adolescents average about 8 peaks per 24 hours.
Adults average about 5 peaks. Basal levels and the
frequency and amplitude of peaks decline throughout
adult life.
The primary biological actions of the hormone are in
direct growth promoting. HGH exerts its effect directly
on target organs such as cartilage, bones and
muscles and indirectly through the release of insulinlike
growth factor (IGF), produced in the liver (2). In
particular, somatotropin C (IGF-1) is essential for
bone growth during childhood.
Generally increases protein synthesis and stimulates
the growth of all internal organs excluding the brain.
GH reduces liver uptake of glucose, an effect that
opposes that of insulin. GH also contributes to the
maintenance and function of pancreatic islets. GH
stimulates the immune system.
GH can cause excessive growth, traditionally referred
to as pituitary giganttism.
Deficiency of GH produces significantly different
problems at various ages. In children, growth failure
and short stature are the major manifestations of GH
deficiency. In adults the effects of deficiency are more
subtle, and may include deficiencies of strength,
energy, and bone mass, as well as increased
cardiovascular risk.
Diagnosis of GH deficiency involves a multiple step
diagnostic process, usually culminating in GH
stimulation test(s) to see if the patient's pituitary gland
will release a pulse of GH when provoked by various
stimuli.
synthesised and secreted by the anterior pituitary
gland which stimulates growth and cell reproduction in
humans and other vertebrate animals.
GH is released from the pituitary into the bloodstream
in a pulsatile manner under the regulatory control of
hypothalamic somatostatin (SS) and GH-releasing
factor (GHRF).
Stimulators of GH secretion include, exercise,
hypoglycemia, dietary protein, and estradiol. Inhibitors
of GH secretion include dietary carbhoydrate and
glucocorticoids.
Almost 50% of GH in circulation is bound to a high
affinity GH binding protein (GHBP), which represents
the extracellular domain of the GH receptor.
The plasma concentration of GH during these peaks
may range from 5 to 30 ng/mL or more. Peaks
typically last from 10 to 30 minutes before returning to
basal levels. The largest and most predictable of
these GH peaks occurs about an hour after onset of
sleep. Otherwise there is wide variation between days
and individuals. Between the peaks, basal GH levels
are low, usually less than 3 ng/mL for most of the day
and night.
The amount and pattern of GH secretion change
throughout life. Basal levels are highest in early
childhood. The amplitude and frequency of peaks is
greatest during the pubertal growth. Healthy children
and adolescents average about 8 peaks per 24 hours.
Adults average about 5 peaks. Basal levels and the
frequency and amplitude of peaks decline throughout
adult life.
The primary biological actions of the hormone are in
direct growth promoting. HGH exerts its effect directly
on target organs such as cartilage, bones and
muscles and indirectly through the release of insulinlike
growth factor (IGF), produced in the liver (2). In
particular, somatotropin C (IGF-1) is essential for
bone growth during childhood.
Generally increases protein synthesis and stimulates
the growth of all internal organs excluding the brain.
GH reduces liver uptake of glucose, an effect that
opposes that of insulin. GH also contributes to the
maintenance and function of pancreatic islets. GH
stimulates the immune system.
GH can cause excessive growth, traditionally referred
to as pituitary giganttism.
Deficiency of GH produces significantly different
problems at various ages. In children, growth failure
and short stature are the major manifestations of GH
deficiency. In adults the effects of deficiency are more
subtle, and may include deficiencies of strength,
energy, and bone mass, as well as increased
cardiovascular risk.
Diagnosis of GH deficiency involves a multiple step
diagnostic process, usually culminating in GH
stimulation test(s) to see if the patient's pituitary gland
will release a pulse of GH when provoked by various
stimuli.