H5N1-M2 Antibody

h1 class=titleH5N1-M2 Antibody/h1
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h4Catalog Number/h4
pstrong250681/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pAvian influenza Matrix Protein-2 (H5N1-M2) forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pAvian influenza Matrix Protein-2; Matrix protein 2; Proton channel protein M2; H5N1; H5N1-M2; Influenza A virus/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/O70632O70632/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the N-term region of influenza A virus matrix protein 2./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:100-1:500/p
pIHC: 1:100-1:500/p
pstrongReacts with/strongnbsp; :Other/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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