Antibodies
GW441756
- 貨號 Cat. No.
- S2891
- 規格 Size
- 5~200mg
- 品牌 Brand
- Selleckchem
Description
GW441756
Catalog No.S2891
GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. | |||||
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| Targets | TrkA | |||||
| IC50 | 2 nM[1] | |||||
| In vitro | GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production[2] and apoptosis in TrkA-overexpressing cells. [3] | |||||
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| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 275.3 |
|---|---|
| Formula | C17H13N3O |
| CAS No. | 504433-23-2 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 25 mg/mL (90 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]- |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.2753 | 2.753 | 5.506 | 8.259 |
