GW2580

Alternate Name/Synonyms: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 870483-87-7

Molecular Formula: C₂₀H₂₂N₄O₃

Molecular Weight: 366.41

Purity: ≥99% by HPLC

Solubility: DMSO (40 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases.  GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. 

Handling: Protect from air and light