GW2580
- 貨號 Cat. No.
- 1740-5
- 規格 Size
- 5 mg
Description
Alternate Name/Synonyms: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 870483-87-7
Molecular Formula: C₂₀H₂₂N₄O₃
Molecular Weight: 366.41
Purity: ≥99% by HPLC
Solubility: DMSO (40 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: A small-molecule, ATP-competitive inhibitor of cFMS kinase; at 60 nM it inhibits human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 also inhibits lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro.
Handling: Protect from air and light