GR Antibody

The glucocorticoid receptor (GR) is a receptor for glucocornticoids (GC) and has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (cRE) and as a modulator of other transcription factors. GR affects inflammatory responses, as well as cellular proliferations and differentiation in target tissues. GR is cytoplasmic in the absence of ligand, and nuclear after ligand-binding. GR belongs to the nuclear hormone receptor (NR3) sub family. GR contains 1 nuclear receptor DNA- binding domain.