GPR108 Antibody (LS-A2106)

Description

GPR108 (LUSTR2) is a seven-transmembrane family protein that activates NF-?B strongly when overexpressed. It acts as an antagonist of Toll-like receptor (TLR)-mediated signaling. Upon TLR stimulation GPR108 abundance increases and the protein engages TLRs and their partners to reduce MyD88 expression and interfere with its binding to TLR4 through blocking MyD88 ubiquitination. In turn GPR108 is antagonized by TIRAP, an adaptor protein for TLR and MyD88. GPR108 and innate immune signaling components are multifactorial. It is expressed in many tissues in the human body. References: https://doi.org/10.1371/journal.pone.0205303

Target

Human GPR108

Synonyms

GPR108 | G protein-coupled receptor 108 | LUSTR2 | Protein GPR108

See All GPR108 Antibodies

Host

Rabbit

Reactivity

Human (tested or 100% immunogen sequence identity)

Predicted

Monkey (at least 90% immunogen sequence identity)

Clonality

Polyclonal

Conjugations

Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.

Purification

Immunoaffinity purified

Modifications

Unmodified

Applications