GNF-5
Chemical Compounds
- 貨號 Cat. No.
- M2603
- 品牌 Brand
- No Brand
Description
GNF-5 is a cell-permeable GNF-2 N-hydroxyethyl carboxamide analog.It exhibits in vivo efficacy in suppressing the proliferation of Bcr-abl-expressing Ba/F3 in murine xenograft models of leukemia.GNF-5 shows potent antiproliferative activity with EC50 of 430 nM and 580 nM against wt-Bcr-Abl and E255K mutant Bcr-Abl transformed cells, respectively. GNF-5 is ineffective toward the myristate-binding site mutant E505K and the ATP-binding site 'gatekeeper' mutant T315I.
