Glutathion-S-Transferase π (GST-π) EIA

Glutathion-S-transferases (GST) are a group of enzymes, which are involved
in detoxification processes. The GSTs are divided in 5 subgroups: Alpha, Mu,
Pi, Teta and microsomal. The classes differ in their physicochemical,
immunological, enzymatic and structural properties. Their function in
cellular metabolism is the coupling of electrophile compounds, for example
most of the carcinogens, to Glutathion (GSH). The GST Pi is the main group
in erythrocytes and in some leucocytes, moreover they are found in most
tissues except liver. The GST Pi are dimeric molecules with a molecular
weight of 46000 Da and an isoelectric point of about 4.7. High GST Pi levels
were found in all neoplastic tissue (fetal, maligne) and in serum of patients
with post-operative relapse. Increased serum levels were also found in
haematological diseases (haemolytic anaemia and sub-groups of leukemia).
Moreover GST Pi concentrations give information about the multi-drugresistance-status
of tumours