Gliadin Peptide (4F3) Antibody

h1 class=titleGliadin Peptide (4F3) Antibody/h1
div id=node-638 class=node ntype-antibodiesMouse Monoclonal
div class=contentstyle type=text/css
!--
h4 {
margin: 30px 0 0 0;
padding: 0;
border-top: 1px solid #bbb;
background: #f8f8f8;
}
--/style
div class=product-table
table border=0 cellspacing=10 cellpadding=0 width=100%
tbody
tr
td valign=top width=50%
h4Catalog Number/h4
pstrong250438/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
h4
pnbsp;/p
Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
pnbsp;/p
h4Data and Images/h4
/td
td valign=top
h4Description/h4
pCeliac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody cross-reacts fully with the non-deamidated peptide KLQPFPQPQLPYPQPQ/p
br style=clear: both /
br style=clear: both /
h4Product Citations/h4
pnbsp;/p
h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/gliadin-peptide-%2814d5%29-antibody250437 Gliadin Peptide (14D5) Antibody/abr /
nbsp;/p
h4Alternate Names/h4
pAlpha gliadin/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q41531Q41531/abr /
nbsp;/p
h4Clonality/h4
p4F3/p
h4Antigen/h4
pnbsp;/p
pGliadin-related peptide Lys57-Glu65-[alpha-gliadin (58-73)] (KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein./p
pnbsp;/p
h4Application Notes/h4
pnbsp;/p
pProduct Cat. No. 250438 reacts equally strong in ELISA with the deamidated gliadin-related peptide (KLQPFPQPELPYPQPQ) and the non-deamidated gliadin-related peptide (KLQPFPQPQLPYPQPQ) coated directly in microplate./p
pE: 1:20,000/p
pstrongReacts with/strongnbsp; :Other/p
pnbsp;/p
h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
/td
/tr
/tbody
/table
/div
/div
/div