GFRalpha-1 Antibody
- 貨號 Cat. No.
- 6201-100
- 規格 Size
- 100 µg
Description
pstrongAntibody Target :/strongGFRa-1/p
pstrongHost: Rabbit /strong/p
pstrongAntibody Type: Polyclonal /strong/p
pstrongIsotype: Rabbit IgG /strong/p
pstrongAntibody Form: Affinity Purified Antibody /strong/p
pstrongImmunogen Sequence: Synthetic Peptide to amino acids 369-382 of human GFRalpha;-1 /strong/p
pstrongAccession#: P56159 /strong/p
pstrongGene ID: 2674 /strong/p
pstrongAppearance: Colorless liquid /strong/p
pstrongConcentration: 0.5 mg/ml /strong/p
pstrongFormulation: 100 micro;g (0.5 mg/ml) immunoaffinity purified rabbit anti-GFRalpha;-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. /strong/p
pstrongPurification: Affinity purified /strong/p
pstrongSpecies Reactivity: hu/ms/rt /strong/p
pstrongApplication: WB /strong/p
pstrongApplication amp; Usage: Western blot analysis (0.5-4 micro;g/ml). However, the optimal conditions should be determined individually. /strong/p
pstrongStorage Temp.: -20 deg;C /strong/p
pstrongShipping : gel pack /strong/p
pstrongShelf Life: 12 months /strong/p
pstrongHandling: The antibody solution should be gently mixed before use. /strong/p
pstrongBrief Background Descriptions: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha;, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRalpha; from human, rat, chicken and mouse have been cloned recently. GDNFRalpha;was also termed Ret ligand 1 (RETL1) or TGF-beta;-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha;-1 recently. GFRalpha;-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha; and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function./strong/p
pstrongHost: Rabbit /strong/p
pstrongAntibody Type: Polyclonal /strong/p
pstrongIsotype: Rabbit IgG /strong/p
pstrongAntibody Form: Affinity Purified Antibody /strong/p
pstrongImmunogen Sequence: Synthetic Peptide to amino acids 369-382 of human GFRalpha;-1 /strong/p
pstrongAccession#: P56159 /strong/p
pstrongGene ID: 2674 /strong/p
pstrongAppearance: Colorless liquid /strong/p
pstrongConcentration: 0.5 mg/ml /strong/p
pstrongFormulation: 100 micro;g (0.5 mg/ml) immunoaffinity purified rabbit anti-GFRalpha;-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. /strong/p
pstrongPurification: Affinity purified /strong/p
pstrongSpecies Reactivity: hu/ms/rt /strong/p
pstrongApplication: WB /strong/p
pstrongApplication amp; Usage: Western blot analysis (0.5-4 micro;g/ml). However, the optimal conditions should be determined individually. /strong/p
pstrongStorage Temp.: -20 deg;C /strong/p
pstrongShipping : gel pack /strong/p
pstrongShelf Life: 12 months /strong/p
pstrongHandling: The antibody solution should be gently mixed before use. /strong/p
pstrongBrief Background Descriptions: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha;, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRalpha; from human, rat, chicken and mouse have been cloned recently. GDNFRalpha;was also termed Ret ligand 1 (RETL1) or TGF-beta;-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha;-1 recently. GFRalpha;-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha; and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function./strong/p