Gefitinib

Alternate Name/Synonyms: ZD-1839

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 184475-35-2

Molecular Formula: C₂₂H₂₄ClFN₄O₃

Molecular Weight: 446.9

Purity: ≥99% by HPLC

Solubility: DMSO (100 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 µM). The ICâ‚…â‚€ values for Gefitinib to inhibit HT-29 and LoVo cell growth were 23.6 - >100 µM and 7.3 - 48.5 µM, respectively, when the exposure times are from 18 hours to 3 days. The IC50 values of Gefitinib to the breast cancer cell lines BT20, HCC1937, MDA-MB-231, BT474, and SKBR3 are 15.5±1.4, 8.4±1.5, 20.7±1.1, 0.25±0.05, 0.88±0.31 µM, respectively

Handling: Protect from light and moisture