GDC-0941
- 貨號 Cat. No.
- 1623-5
- 規格 Size
- 5 mg
Description
Alternate Name/Synonyms: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 957054-30-7
Molecular Formula: C₂₃H₂₇N₇O₃S₂
Molecular Weight: 513.64
Purity: ≥99% by HPLC
Solubility: DMSO
Storage Temp.: -20°C
Shipping Conditions: RT
Description: GDC-0941 is a potent inhibitor of p110α and p110δ (ICâ‚…â‚€ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.
Handling: Protect from air and light