FTY-720 HCl/Fingolimod hydrochloride (5 mg)

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Fingolimod Hydrochloride; CAS # 162359-56-0; FTY720; Fingolimod HCl; Gilenia; Gilenya; Fty 720

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Fingolimod (FTY720) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells.

 

Background_Info : Fingolimod (FTY720) is a sphingosine 1-phosphate receptor modulator indicated and approved for the treatment of relapsing-remitting multiple sclerosis. Fingolimod (trade name Gilenya, Novartis) is metabolized by sphingosine kinase to the active metabolite, fingolimod-phosphate. Fingolimod-phosphate is a sphingosine 1-phosphate receptor modulator, and binds with high affinity to sphingosine 1-phosphate receptors 1, 3, 4, and 5. Fingolimod-phosphate blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. The mechanism by which fingolimod exerts therapeutic effects in multiple sclerosis is unknown, but may involve reduction of lymphocyte migration into the central nervous system. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials.

 

Clone_Name
(AB only, monoclonals) :

 

Datasheet_Link : https://www.biosensis.com/pdf_datasheet.php?products_id=1825

 

Description (Long Description) : 

Pharmacology: An analog of sphingosine which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3) (1). Potently inhibits regulatory T cell proliferation in vitro and in vivo (2). Enhances microvascular remodeling via expansion of arterioles and capillary networks (3). Potent immunomodulator (4). Clinically effective agent for relapsing forms of multiple sclerosis (5). PubChem CID:107969; Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.

 

Expiry_Date : 

See storage conditions.

 

Format (Form) : 

Dry powder; Off-white powder

 

Immunogen (Antigen) :343.9 g/mol. Molecular Formula: C19H34ClNO2

 

Kit_Components :

 

MSDS (File name) :https://www.biosensis.com/pdf_MSDS.php?products_id=1825