Flupenthixol dihydrochloride

Flupenthixol dihydrochloride is a non-selective antagonist at D1 and D2 receptors. Flupenthixol dihydrochloride is a antagonist at dopamine (D1-D5), serotonin (5-HT2), adrenergic (α1) and histamine (H1) receptors. Flupenthixol dihydrochloride has antipsychotic properties in vivo. A single-blind, parallel group, general practice study was carried out in 153 patients with mild to moderate depression to compare the efficacy and tolerability of flupenthixol dihydrochloride and dothiepin hydrochloride. Both drugs were well tolerated, although persistence of anticholinergic side-effects in the dothiepin group resulted in a trend favouring flupenthixol. One patient in the flupenthixol group attempted suicide by overdose but made a complete recovery.