FLASH Polyclonal Antibody
- 貨號 Cat. No.
- 3219-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= /nbsp;/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 1256 of human FLASH/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-FLASH polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bA novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. FLASH is widely expressed./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-2 ug/ml). However, the optimal conditions should be determined individually. Other applications have not been tested./p
pbSPECIFICITY: /bThe immunoaffinity purified antibody detects an approximately 220 kDa human FLASH by Western blot analysis./p
pbFOR RESEARCH USE ONLY! Not to be used in human. /b/p
pfont size=2 /font/p
pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 1256 of human FLASH/p
pbFORMULATION: /b100 ug (0.5 mg/ml) peptide affinity purified rabbit anti-FLASH polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal./p
pbSPECIES REACTIVITY: /bhuman/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bA novel mammalian CED-4 homologous was recently identified and cloned in mouse and human and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. FLASH is widely expressed./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blot analysis (0.5-2 ug/ml). However, the optimal conditions should be determined individually. Other applications have not been tested./p
pbSPECIFICITY: /bThe immunoaffinity purified antibody detects an approximately 220 kDa human FLASH by Western blot analysis./p
pbFOR RESEARCH USE ONLY! Not to be used in human. /b/p