FK-506

Alternate Name/Synonyms: Tacrolimus

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 104987-11-4

Molecular Formula: C₄₄H₆₉NO₁₂

Molecular Weight: 804.02

Purity: ≥98%

Solubility: DMSO (20 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium. FK506 and rapamycin, but not cytosporin inhibit aldosterone-stimulated sodium transport in A6 cells.

Handling: Protect from light and moisture