FITC-Labeled Human CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free

Source : 

FITC-Labeled Human CD8A&CD8B Heterodimer Protein, His Tag&Tag Free (CDA-HF2W4) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Asp 182 (CD8A) & Leu 22 - Pro 170 (CD8B) (Accession # P01732-1 (CD8A) & P10966-1 (CD8B)). It is the FITC labeled form of Human CD8A&CD8B Heterodimer Protein, His Tag&Tag Free (CDA-H52W5).

 

Molecule : CD8 alpha & beta

 

Synonyms : CD8 alpha & beta,CD8A & CD8B

 

Format : Powder

 

Category : Fluorescent labeled protein

 

Accession : NP_001759.3 (CD8A) | NP_004922.1 (CD8B)

 

Storage : -20℃, aviod light

 

Shipping condition : Powder,RT, Avoid light

 

Molecular Weight : 19.5 kDa (CD8A) & 22.1 kDa (CD8B)

 

Characteristics :

FITC-Labeled Human CD8A&CD8B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of CD8 alpha and CD8 beta, has a calculated MW of 19.5 kDa (CD8 alpha) and 22.1 kDa (CD8 beta). Subunit CD8 alpha is fused with a polyhistidine tag at the C-term

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. CD8A forms disulfide-linked heterodimers with CD8B at the cell surface. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Additionally, CD8B plays a critical role in thymic selection of CD8+ T-cells. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched.

 

References :

(1) Arcaro A, et al. J Exp Med. 2001. 194(10):1485-95.
(2) Lyons GE, et al. Cancer Res. 2006. 66(23):11455-61.