Fibulin-5 Antibody

Fibulin-5 promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Fibulin-5 is a vascular ligand for integrin receptors and may play a role in vascular development and remodeling. Defects in fibulin-5 are a cause of autosomal dominant cutis laxa (ADCL). Hereditary cutis laxa refers to a heterogeneous group of connective tissue disorders characterized by cutaneous abnormalities and variable systemic manifestations. The most constant clinical feature is loose skin, sagging over the face and trunk.