FGR (6G2) Antibody

FGR (Gardner-Rasheed feline sarcoma viral oncogene homolog) is a member of the Src family of protein tyrosine kinases (PTKs). FGR contains N-terminal sites for myristylation and palmitylation, a PTK domain, SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene.