FBXW8 Antibody

F-box/WD repeat-containing protein 8 (FBXW8) is a substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteosomal degradation of target proteins. FBXW8 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box.