FasL Antibody

Tumor necrosis factor ligand superfamily member 6 (Fas ligand, FasL) is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.