FAP-1 (K366) Antibody

貨號 Cat. No.

BS1121

規格 Size

100μg

品牌 Brand

Bioworld

Description

stock

Host: Rabbit

Reactivity: Human,Mouse,Rat

 

Product

1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Purification & Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity

FAP-1 (K366) antibody detects endogenous levels of FAP-1 protein.

Applications (Recommended Dilutions)

WB: 1:500~1:1000 IHC: 1:50~1:200

Western Blot(WB)

Western blot (WB) analysis of FAP-1 (K366) antibody in extracts from LOVO cells.

Immunohistochemistry (IHC)

Immunohistochemistry (IHC) analyzes of FAP-1 (K366) antibody in paraffin-embedded human breast carcinoma tissue.

Storage&Stability

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Background

In contrast to the growth factors which promote cell proliferation, FAS ligand(Fas-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis.Cellular response to Fas-L and TNF is mediated by structurally-related receptors containing a conserved “death domain” belonging to the TNF receptor superfamily. Putative downstream receptors of FAS include TRADD, FADD and RIP. A novel protein tyrosine phosphatase, Fap-1 (for FAS-associated phosphatase) (originally designated PTP-BAS), has been shown to associate with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino acids in length. Although lacking a transmembrane region, Fap-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. Fap-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII.

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