FADD Antibody

FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels.