Ezatiostat

Ezatiostat inhibits the enzyme, glutathione S-transferase P1-1, GSTP1-1 is a key regulatory protein that can signal the cell to either make more blood elements or if the cell is cancerous to die.This inhibition induces a dissociation of GST P1-1 from its complex with c-jun N-terminal kinase (JNK)/c-Jun and activates signaling pathways that lead to cell proliferation and differentiation of normal hematopoietic cells and apoptosis of malignant cells.It has shown significant clinical activityof ezatiostat, a glutathione S-transferase P1-1 inhibitor in clinical development for the treatment of low- to intermediate-risk MDS.