Antibodies
EUK 134
- 貨號 Cat. No.
- S4261
- 規格 Size
- 20mgã€50mg
- 品牌 Brand
- Selleckchem
Description
EUK 134
Catalog No.S4261
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril. | |||||
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| In vitro | EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4] | |||||
| In vivo | EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5] | |||||
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Protocol(Only for Reference)
Animal Study: [1]
| Animal Models | Rat model in stroke. |
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| Dosages | ~2.5 mg/kg |
| Administration | i.v. |
References
Chemical Information
| Molecular Weight (MW) | 416.74 |
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| Formula | C18H18ClMnN2O4 |
| CAS No. | 81065-76-1 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 83 mg/mL (199 mM) |
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| Water | 13 mg/mL (31 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | chloro[[2,​2’-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[6-​methoxyphenolato-​κO]]]-​manganese |
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