Estrogen Receptor (ERα) (Human) ELISA Kit

Alternate Name :

Tag Line :

An Sandwich ELISA kit for the quantitative measurement of human ER-alpha in human serum, plasma, culture supernatants and other biological fluids

Storage Conditions: 4°C

Shelf life: 6 months

Summary :

• Detection method- Absorbance (450 nm)
• Species reactivity- Human
• Application- quantitative measurement of ER-alpha in human serum, plasma, tissue homogenates and other biological fluids.

Detection Method: Absorbance (450 nm)

Features & Benefits:

Easy, convenient and time-saving method to measure the level of ER-alpha in human serum, plasma, tissue homogenates, culture supernatants and other biological fluids.
Detection Range: 62.5-4000 pg/ml
Sensitivity: < 37.5 pg/ml

Description:

Estrogen Receptor is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. BioVision’s ER-alpha ELISA kit is a sandwich ELISA assay for the quantitative measurement of human ER-alpha in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of human ER-alpha captured from the samples.