ER-beta Antibody

h1 class=titleER-beta Antibody/h1
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h4Catalog Number/h4
pstrong250639/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pEstrogen and progesterone receptors are members of a family transcription that are regulated by the binfing of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Anbsp; and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pEstrogen receptor beta; ER; Estradiol receptor; ER-beta; Nuclear receptor subfamily 3 group A member 2; ESR2; ESTRB; NR3A2/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q92731Q92731/abr /
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h4Clonality/h4
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h4Antigen/h4
pnbsp;/p
pKLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-beta./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pIP:Use at an assay dependent concentration/p
pstrongReacts with/strongnbsp; :H | M | R/p
pnbsp;/p
h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment/p
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