Antibodies
Epinastine HCl
- 貨號 Cat. No.
- S4253
- 規格 Size
- 50mg
- 品牌 Brand
- Selleckchem
Description
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h1 itemprop=name style=margin: 0px 20px 0px 0px; padding: 0px; font-size: 24px; float: left;Epinastine HCl/h1
div class=product_c_title style=margin: 0px 20px 0px 0px; padding: 0px; height: 25px; float: left;span class=p_title style=margin: 0px 15px 0px 0px; padding: 0px; float: left;Catalog No.S4253/span/div
p class=new_title style=margin: 5px 0px 10px; padding: 0px; clear: both; font-size: 11px; line-height: 14.399999618530273px;Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis./p
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th width=402 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background: rgb(221, 228, 236);nbsp;/th
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td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;50mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 122/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
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h3 id=biologicalActivity style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Biological Activity/h3
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th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Description/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis./td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Targets/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);IC50/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vitro/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spanEpinastine is able to displace specific [span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spanH]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;i/spannbsp;of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Caspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;2+/spanuptake into lung mast cells in actively sensitized guinea pigs but also Caspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;2+/spannbsp;release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[3]/a/spannbsp;Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/span/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vivo/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/td
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th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Features/th
td colspan=6 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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h3 id=protocol style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Protocolspan style=margin: 0px; padding: 0px; font-weight: normal;(Only for Reference)/span/h3
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h4 class=reference margin_t style=margin: 10px 0px 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;References/h4
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Chemical Information/h3
pa href=http://file.selleckchem.com/downloads/product-sdf/Epinastine-HCl-s4253.SDF style=margin: -25px 0px 0px 180px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; float: left;Download Epinastine HCl SDF/a/p
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;nbsp;/div
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Molecular Weight (MW)/th
td width=55% style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);285.77/td
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formula/th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);
p style=margin: 0px; padding: 0px;Cspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;16/spanHspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;15/spanNspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;3/span.HCl/p
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th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);CAS No./th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);108929-04-0/td
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table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab fr style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: right;
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th rowspan=2 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Storage/th
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);3 yearsnbsp;span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-20℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;Powder/span/td
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td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);6 monthsspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-80℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;in DMSO/span/td
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th width=161 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Syonnyms/th
td width=214 class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);N/A/td
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th width=12% rowspan=3 style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);strong style=margin: 0px; padding: 0px;Solubility (25deg;C)nbsp;/strongspan class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/span/th
td width=10% rowspan=3 class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vitro/td
td width=50% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);DMSO/td
td width=28% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
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td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Water/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
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td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanol/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
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td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;lt;1 mg/ml means slightly soluble or insoluble.br style=margin: 0px; padding: 0px; /
span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
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th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Chemical Name/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-, hydrochloride (1:1)/td
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div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;nbsp;/div
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;a href=http://www.selleckchem.com/molaritycalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molarity Calculator/anbsp;a href=http://www.selleckchem.com/dilutioncalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Dilution Calculator/anbsp;a href=http://www.selleckchem.com/molecular-weight-calculator.html style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molecular Weight Calculator/a/div
div class=new_q_related style=margin: 20px 0px 10px; padding: 0px; float: left; width: 760px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;
h2 style=margin: 0px 0px 10px; padding: 0px; border-bottom-width: 2px; border-bottom-style: solid; border-bottom-color: rgb(53, 87, 148); font-size: 12px; height: 23px;span style=margin: 0px; padding: 4px 15px 2px; display: inline-block; color: rgb(255, 255, 255); background: rgb(53, 87, 148);Customers Who Bought This Item Also Bought/span/h2
div class=new_q_control style=margin: 0px; padding: 0px; float: left; width: 1000px;
ul style=margin: 0px; padding: 0px; list-style: none; width: 800px; overflow: hidden;
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Nilotinib.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Nilotinib (AMN-107)/a
p class=cont style=margin: 3px 0px 0px; padding: 0px; width: 209px; height: 55px; overflow: hidden; color: rgb(102, 102, 102);Nilotinib (AMN-107) is anbsp;b style=margin: 0px; padding: 0px;Bcr-Abl/binhibitor withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;less than 30 nM./p
p class=p2 style=margin: 0px; padding: 0px; width: 209px; height: 50px; color: rgb(102, 102, 102); line-height: 16.200000762939453px; overflow: hidden;span style=margin: 0px 3px 0px 0px; padding: 0px; color: rgb(255, 120, 0); font-weight: bold;Features:/spanA selective inhibitor of native and mutant Bcr-Abl./p
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li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Voriconazole.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Voriconazole/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Quetiapine-fumarate(Seroquel).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Quetiapine Fumarate/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Pitavastatin-calcium(Livalo).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Pitavastatin Calcium/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Pitavastatin calcium is a novel member of the medication class of statins./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/ly2109761.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;LY2109761/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;LY2109761 is a novel selectivenbsp;b style=margin: 0px; padding: 0px;TGF-beta; receptor type I/II (Tbeta;RI/II)/bnbsp;dual inhibitor withnbsp;b style=margin: 0px; padding: 0px;Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;i/span/bnbsp;of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/sb-505124.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;SB505124/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;SB505124 is a selective inhibitor ofb style=margin: 0px; padding: 0px;TGFbeta;R/bnbsp;fornbsp;b style=margin: 0px; padding: 0px;ALK4/b,nbsp;b style=margin: 0px; padding: 0px;ALK5/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 129 nM and 47 nM, respectively, also inhibitsnbsp;b style=margin: 0px; padding: 0px;ALK7/b, but does not inhibit ALK1, 2, 3, or 6./p
/li
/ul
/div
/div
pnbsp;/p
pnbsp;/p
pnbsp;/p
h1 itemprop=name style=margin: 0px 20px 0px 0px; padding: 0px; font-size: 24px; float: left;Epinastine HCl/h1
div class=product_c_title style=margin: 0px 20px 0px 0px; padding: 0px; height: 25px; float: left;span class=p_title style=margin: 0px 15px 0px 0px; padding: 0px; float: left;Catalog No.S4253/span/div
p class=new_title style=margin: 5px 0px 10px; padding: 0px; clear: both; font-size: 11px; line-height: 14.399999618530273px;Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis./p
/div
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td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;50mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 122/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
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h3 id=biologicalActivity style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Biological Activity/h3
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Description/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis./td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Targets/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);IC50/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vitro/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spanEpinastine is able to displace specific [span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spanH]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;i/spannbsp;of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Caspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;2+/spanuptake into lung mast cells in actively sensitized guinea pigs but also Caspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;2+/spannbsp;release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[3]/a/spannbsp;Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/span/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vivo/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/epinastine-hcl.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/td
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tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Features/th
td colspan=6 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
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/tbody
/table
h3 id=protocol style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Protocolspan style=margin: 0px; padding: 0px; font-weight: normal;(Only for Reference)/span/h3
pa id=s_ref style=margin: 0px; padding: 0px; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; clear: both; float: left; height: 0px; font-size: 0px;1/a/p
h4 class=reference margin_t style=margin: 10px 0px 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;References/h4
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Chemical Information/h3
pa href=http://file.selleckchem.com/downloads/product-sdf/Epinastine-HCl-s4253.SDF style=margin: -25px 0px 0px 180px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; float: left;Download Epinastine HCl SDF/a/p
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table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab01 fl style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: left;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Molecular Weight (MW)/th
td width=55% style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);285.77/td
/tr
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formula/th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);
p style=margin: 0px; padding: 0px;Cspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;16/spanHspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;15/spanNspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;3/span.HCl/p
/td
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tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);CAS No./th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);108929-04-0/td
/tr
/tbody
/table
table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab fr style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: right;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th rowspan=2 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Storage/th
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);3 yearsnbsp;span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-20℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;Powder/span/td
/tr
tr style=margin: 0px; padding: 0px;
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);6 monthsspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-80℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;in DMSO/span/td
/tr
tr style=margin: 0px; padding: 0px;
th width=161 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Syonnyms/th
td width=214 class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);N/A/td
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table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table mb15 style=margin: 0px 0px 15px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229);
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=12% rowspan=3 style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);strong style=margin: 0px; padding: 0px;Solubility (25deg;C)nbsp;/strongspan class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/span/th
td width=10% rowspan=3 class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vitro/td
td width=50% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);DMSO/td
td width=28% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Water/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanol/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);57 mg/mL (199 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;lt;1 mg/ml means slightly soluble or insoluble.br style=margin: 0px; padding: 0px; /
span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
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/div
div style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; height: 10px;nbsp;/div
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tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Chemical Name/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-amine, 9,13b-dihydro-, hydrochloride (1:1)/td
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/table
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;nbsp;/div
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;a href=http://www.selleckchem.com/molaritycalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molarity Calculator/anbsp;a href=http://www.selleckchem.com/dilutioncalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Dilution Calculator/anbsp;a href=http://www.selleckchem.com/molecular-weight-calculator.html style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; border: 1px solid rgb(237, 218, 159); background: rgb(255, 239, 187);Molecular Weight Calculator/a/div
div class=new_q_related style=margin: 20px 0px 10px; padding: 0px; float: left; width: 760px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;
h2 style=margin: 0px 0px 10px; padding: 0px; border-bottom-width: 2px; border-bottom-style: solid; border-bottom-color: rgb(53, 87, 148); font-size: 12px; height: 23px;span style=margin: 0px; padding: 4px 15px 2px; display: inline-block; color: rgb(255, 255, 255); background: rgb(53, 87, 148);Customers Who Bought This Item Also Bought/span/h2
div class=new_q_control style=margin: 0px; padding: 0px; float: left; width: 1000px;
ul style=margin: 0px; padding: 0px; list-style: none; width: 800px; overflow: hidden;
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Nilotinib.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Nilotinib (AMN-107)/a
p class=cont style=margin: 3px 0px 0px; padding: 0px; width: 209px; height: 55px; overflow: hidden; color: rgb(102, 102, 102);Nilotinib (AMN-107) is anbsp;b style=margin: 0px; padding: 0px;Bcr-Abl/binhibitor withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;less than 30 nM./p
p class=p2 style=margin: 0px; padding: 0px; width: 209px; height: 50px; color: rgb(102, 102, 102); line-height: 16.200000762939453px; overflow: hidden;span style=margin: 0px 3px 0px 0px; padding: 0px; color: rgb(255, 120, 0); font-weight: bold;Features:/spanA selective inhibitor of native and mutant Bcr-Abl./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Voriconazole.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Voriconazole/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Quetiapine-fumarate(Seroquel).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Quetiapine Fumarate/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/Pitavastatin-calcium(Livalo).html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;Pitavastatin Calcium/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;Pitavastatin calcium is a novel member of the medication class of statins./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/ly2109761.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;LY2109761/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;LY2109761 is a novel selectivenbsp;b style=margin: 0px; padding: 0px;TGF-beta; receptor type I/II (Tbeta;RI/II)/bnbsp;dual inhibitor withnbsp;b style=margin: 0px; padding: 0px;Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;i/span/bnbsp;of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2./p
/li
li style=margin: 0px 15px 15px 0px; padding: 10px 15px; list-style: none; float: left; width: 213px; height: 125px; line-height: 17.399999618530273px; overflow: hidden; background: rgb(240, 247, 255);a href=http://www.selleckchem.com/products/sb-505124.html style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-weight: bold;SB505124/a
p style=margin: 3px 0px 0px; padding: 0px; color: rgb(102, 102, 102); height: 105px; overflow: hidden;SB505124 is a selective inhibitor ofb style=margin: 0px; padding: 0px;TGFbeta;R/bnbsp;fornbsp;b style=margin: 0px; padding: 0px;ALK4/b,nbsp;b style=margin: 0px; padding: 0px;ALK5/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 129 nM and 47 nM, respectively, also inhibitsnbsp;b style=margin: 0px; padding: 0px;ALK7/b, but does not inhibit ALK1, 2, 3, or 6./p
/li
/ul
/div
/div
pnbsp;/p
pnbsp;/p
pnbsp;/p
