Antibodies
Entacapone
- 貨號 Cat. No.
- S3147
- 規格 Size
- 10mM/1mL~100mg
- 品牌 Brand
- Selleckchem
Description
Entacapone
Catalog No.S3147
Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. | |||||
|---|---|---|---|---|---|---|
| Targets | COMT | |||||
| IC50 | 151 nM [1] | |||||
| In vitro | Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. [1] Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. [2] | |||||
| In vivo | ||||||
| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
| Molecular Weight (MW) | 305.29 |
|---|---|
| Formula | C14H15N3O5 |
| CAS No. | 130929-57-6 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 61 mg/mL (199 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 2 mg/mL (6 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.30529 | 3.0529 | 6.1058 | 9.1587 |
