ENA Profile

Antibodies to extractable nuclear antigens are
characteristic for some rheumatic diseases and can
contribute to the diagnosis and prognosis of systemic
lupus erythematosus (SLE), Sjögren’s syndrome,
mixed-connective tissue disease (MCTD),
scleroderma, poly- and dermatomyositis and CREST
syndrome.
The Diametra ENA Profile allows for the simultaneous
detection of SS-A/Ro-, SS-B/La-, SmD1-, U1-snRNP-, Scl70-, Jo1-, Histone- and Centromere B-specific
autoantibodies.
SS-A / Ro Antigen: SS-A 60, SS-A 52 Sjögren’s
syndrome (~90%), SLE (50%)
SS-B / La Antigen: SS-B Sjögren’s syndrome (85%)
SmD1 Antigen: SmD1 peptide SLE (70%)
U1-snRNP Antigen: RNP-A, RNP-C, RNP 68kD
Mixed Connective Tissue Disease (100%)
Scl70 Antigen: Topoisomerase I Systemic Sclerosis
(70%)
Jo1 Antigen: Histidyl-tRNA-synthetase Polymyositis /
Dermatomyositis (25-30%)
Histone Antigen: Histone 2A, 2B, 3, 4 Drug-induced
SLE (95 %), SLE (20-50%)
Centromere B Antigen: Centromere-associated
protein B (80kD) CREST syndrome (Calcinosis,
Raynaud phenomenon, Esophageal dysmotility,
Sclerodactyly and Telangiectasia)