EGFRvIII Antibody

h1 class=titleEGFRvIII Antibody/h1
div id=node-1479 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250632/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pEpidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFRvIII has an 801-bp in-frame deletion resulting in a shorter extracellular domain (aa 6-273 are deleted) with generation of a glycine residue at the fusion point. EGFRvIII is tumor specific and is not expressed in normal human tissues. Defects in EGFR are associated with lung cancer./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pEpidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1; EGFR; ERBB1; EGFRvIII; EGFR variant III/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P00533P00533/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EGFRvIII./p
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h4Application Notes/h4
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pProduct Cat. No. 250632 detects in western blot a 130-kDa band corresponding to truncated EGFR.nbsp;/p
pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R | Other/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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