EGFR, Mouse Antibody

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Epidermal growth factor receptor; ERBB; ERBB1; HER1; mENA; PIG61; NISBD2

 

Antibody_Isotype
(Antibody only) : IgG1kappa

 

Application_Details :

The antibody binds specifically to EGFR, a cell-surface receptor which is part of the ErbB family of receptors. The EGFR is a receptor tyrosine kinase, which, upon activation by its ligands, such as epidermal growth factor and transforming growth factor alpha, triggers signal transduction pathways that increase cell migration, adhesion and proliferation. Mutations that lead to the overexpression of EGFR are associated with the development of cancer. The S3 12D antibody is prepared from isolation of phage antibodies of the spleen library.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : S3 12D

 

Datasheet_Link :

 

Description (Long Description) : 

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv antibody fragment format, for improved compatibility with existing reagents, assays and techniques. The antibody binds specifically to EGFR, a cell-surface receptor which is part of the ErbB family of receptors. The EGFR is a receptor tyrosine kinase, which, upon activation by its ligands, such as epidermal growth factor and transforming growth factor alpha, triggers signal transduction pathways that increase cell migration, adhesion and proliferation. Mutations that lead to the overexpression of EGFR are associated with the development of cancer. The S3 12D antibody is prepared from isolation of phage antibodies of the spleen library.

 

Expiry_Date : 

12 months after purchase if unopened.

 

Format (Form) : 

Liquid, PBS with 0.02% Proclin 300.

 

Immunogen (Antigen) :Human EGFR.

 

Kit_Components :

 

MSDS (File name) :