EGFR Isoform 3

Epidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFR isoform 3 (sEGFR, p110) is a 77 kDa isoform consisting of the extracellular EGFR domain and a unique, truncated carboxy terminus region without transmembrane domain. EGFR isoform 3 is being investigated as a marker for epithelial ovarian cancer. This antibody is specific for isoform 3, it will not recognized full-length EGFR and EGFR vIII.