E-64

Alternate Name/Synonyms: trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide

Appearance: White crystalline solid

Formulation: N/A

CAS Number: 66701-25-5

Molecular Formula: C₁₅H₂₇N₅O₅

Molecular Weight: 357.41

Purity: ≥99% by HPLC

Solubility: DMSO (25 mg/ml) or H2O (20 mg/ml)

Storage Temp.: +4°C

Shipping Conditions: RT

Description: E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. A very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition and displays low toxicity.

Handling: Protect from air and moisture