DR4 Polyclonal Ab
- 貨號 Cat. No.
- 3061-100
- 規格 Size
- 100 ug
Description
pimg src=http://www.biovision.com/Merchant2/graphics/00000001/antibody-stock-miva.jpg alt= /nbsp;/p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN:/strong Synthetic peptide corresponding to residues surrounding amino acids 430 of human DR4. br /
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strongSPECIES REACTIVITY: /stronghuman, mouse, ratbr /
br /
strongFORMULATION: br /
/strong100 ug (0.5 mg/ml) affinity purified rabbit anti-DR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.br /
br /
strongSTORAGE CONDITIONS: br /
/strongStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION: br /
/strongApoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family through their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4 (death receptor 4) and TRAIL-R1. The ligand for this novel death receptor has been identified and termed TRAIL. DR4 is expressed in most of the human tissues including spleen, peripheral blood leukocytes (PBLs), small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NFkB activation in many tissues and cells.br /
br /
strongSPECIFICITY:br /
/strongThe antibody detects a 57 kDa human DR4. HeLa or Jurkat cell lysate can be used as a positive control. br /
br /
strongAPPLICATION AND USAGE: br /
/strongThe antibody can be used for Western blot analysis (0.5-4ug/ml) and immunofluorescence. However, the optimal conditions should be determined individually. br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in humans.br /
/strong/font/p
pfont size=2strongHOST: /strongRabbitbr /
br /
strongIMMUNOGEN:/strong Synthetic peptide corresponding to residues surrounding amino acids 430 of human DR4. br /
br /
strongSPECIES REACTIVITY: /stronghuman, mouse, ratbr /
br /
strongFORMULATION: br /
/strong100 ug (0.5 mg/ml) affinity purified rabbit anti-DR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.br /
br /
strongSTORAGE CONDITIONS: br /
/strongStore at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles.br /
br /
strongBACKGROUND DESCRIPTION: br /
/strongApoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family through their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4 (death receptor 4) and TRAIL-R1. The ligand for this novel death receptor has been identified and termed TRAIL. DR4 is expressed in most of the human tissues including spleen, peripheral blood leukocytes (PBLs), small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NFkB activation in many tissues and cells.br /
br /
strongSPECIFICITY:br /
/strongThe antibody detects a 57 kDa human DR4. HeLa or Jurkat cell lysate can be used as a positive control. br /
br /
strongAPPLICATION AND USAGE: br /
/strongThe antibody can be used for Western blot analysis (0.5-4ug/ml) and immunofluorescence. However, the optimal conditions should be determined individually. br /
br /
strongFOR RESEARCH USE ONLY! Not to be used in humans.br /
/strong/font/p